I relate so painfully well to all the women in The Hours, but particularly Virginia Woolf and Julianne Moore's character. That scene when the latter's husband leaves for the day on his birthday, and she turns to look at her son sitting there, and you know she's thinking, "What the hell am I gonna do with him all day?" But not in the usual put-upon but otherwise content mother kind of way - in a clinically depressed kind of way. I was going through it at the time I saw this movie, and though my son was only two months old at the time, she just really resonated there - so much so that I was filled with this dread like, "Oh, God - what if that's what my life is going to become?"
Also, Nicole Kidman looking in the mirror at herself at one point, with those blank, blank eyes, but yet with fear behind them. She totally nailed what clinical depression looks like. You look at yourself in the mirror, and you see someone you don't recognize looking back at you. It's terrifying, but you're too numb to feel even terror fully.