Jake Gyllenhaal and Gwyneth Paltrow in Proof
Tom Hanks and Audrey Tatoo in The Da Vinci Code
Kirsten Dunst with anybody in anything since Interview with a Vampire. I don't think there's chemistry between her and Tobey Maguire. I find her Mary Jane annoying, (or is it her? can't tell)
I didn't like Julia Roberts and George Clooney in any of Ocean's movies they've been together. I'm finding Julia Roberts annoying lately. I liked her better when she wasn't that famous.
Hugh Grant in almost exactly the same role
Hugh Grant always plays the same role. Always.