Ooh. I love it.
Of course Michelle, Anne, Roberta and Kate
Ralph Fiennes and Ben Kingsley in "Schindler's List"
Steve Buscemi in "Fargo"
The entire cast of "The Usual Suspects" (Ed particularly liked Pete Postelthwaite, I, Benicio Del Toro and Kevin Pollack)
Zooey Deschanel in "The Good Girl"
John C. Reilly in "Chicago"
Klaus Maria Brandauer in "Out of Africa"
Jeff Daniels in "Terms of Endearment"
Catherine Keener in "Capote"
James Gandolfini in "The Mexican"
Denholm Elliot in everything he ever did, but particularly "Breaker Morant"
Chris Cooper in everything he's ever done, but especially "Sea Biscuit" and "October Sky"
Sir John Gielgud in "Arthur" ("On the other hand, go screw yourself." One of the best lines and deliveries of one ever)
Paul Scofield in "Quiz Show"
Helen Mirren in "The Madness of King George" (if you don't consider her a lead)
Billy Connoly in "Mrs. Brown"
Patricia Clarkson in "The Station Agent"
James Belushi in "About Last Night"
Casey Affleck in "Good Will Hunting"
Judi Dench, Imelda Staunton, and Geoffrey Rush in "Shakespeare in Love"
Dennis Quaid in "Breaking Away"
Mickey Rourke in "Diner"
Billy Crudup in "Almost Famous"
Hugh Laurie in "Sense and Sensibility"
Haley Joel Osment in "The Sixth Sense"
Bryan Brown in "The Thornbirds"