Hi Lee, yes David Letterman is from Indy. He used to do the news and the weather here years and years ago. I forget what channel, but he was constantly playing pranks on the others at the studio, live on TV most of the time. He especially enjoyed playing pranks on the women. I remember one time he let a mouse loose in the studio while they were on the air.
His Mother still lives here. He comes to Indy quite often to see her. And he owns one of the race cars in the Indianapolis 500, I think.