Yeah, I saw it when it first screened in LA about a month ago. JCM is great at giving his character real life and blood. Both James and Sophia were able to make me care about them. From what I've read, JMC really collaborated with the actors to create the characters. As strange and messed up as they are, they're still very human. I thought the ending might have fallen apart a bit, but the characters were able to pull it together. And boy! don't you wish there was a place like the Shortbus near you somewhere.
and as a warning, since Imp didn't go into too much detail about the first scene. It very explicitly shows people in sexual situations, with 2 ejaculatory shots. It can be shocking, but it makes sense in the context of the film, imo.