Just thinking out loud here, but I thought someone else might benefit from this. I you play an "A" on this game, that means that you can also play a D, G, J, M, P, S, V, and Y.
But if you hold off until B, then you can play a E, H, K, N, Q, T, W, and Z.
If your first play is a C, then you can go with F, I, L, O, R, U, and X.
This is in a perfect world of course requiring split second timing and no computer laggies or glitches. But I'm hoping to hit all 8 plays one of these rounds. It's one of my fondest ambitions!!